Bivalirudin renal or liver clearance
WebMay 23, 2024 · Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of 25 minutes in PTCA patients with normal renal function. The total body … WebJul 16, 2024 · Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of …
Bivalirudin renal or liver clearance
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WebThe disposition of bivalirudin was studied in PTCA patients with mild, moderate and severe renal impairment. The clearance of bivalirudin was reduced approximately 21% in patients with moderate and severe renal impairment and was reduced approximately 70% in dialysis-dependent patients [see Clinical Pharmacology (12.3)]. WebHalf-life 17 to 21 hours; prolonged in renal impairment, older adults, and low body weight; Possible reversal with andexanet alfa; Apixaban: Oral agent; Eliminated by the kidney …
WebBivalirudin is administered via continuous intravenous infusion, is removed by a combination of proteolytic cleavage by thrombin and renal clearance mechanisms, and can inhibit both soluble and clot-bound thrombin. ... Bivalirudin concentration may be affected by drug interactions, liver, and renal disease. WebOct 17, 2024 · As patients transition between dialysis modalities, and from the intra- to the inter-dialytic period, medications with a narrow therapeutic index that are cleared in …
WebTsu LV and Dager WE. Bivalirudin dosing adjustments for reduced renal function with or without hemodialysis in the management of heparin-induced thrombocytopenia. Ann Pharmacother 2011; 45(10):1185-92. Runyan CL et al. Correlation of bivalirudin dose with creatinine clearance during treatment of heparin-induced thrombocytopenia. WebThe median initial bivalirudin dose to achieve target activated partial thromboplastin time was 0.15 mg/kg/h (range 0.04–0.26 mg/kg/h). Dosing requirements increased by …
WebBivalirudin is administered via continuous intravenous infusion, is removed by a combination of proteolytic cleavage by thrombin and renal clearance mechanisms, and …
WebSep 1, 2011 · Bivalirudin is regularly dose reduced in the setting of renal dysfunction because of its known partial renal clearance. 11 However, dosing guidance for patients supported by CRRT while on ECMO is ... how many gfci outlets in seriesWebThe hepatic clearance is more complex than renal clearance. Like renal clearance, hepatic clearance involves filtering of the blood. Small-molecule drugs, viruses, bacteria or nanoparticles in the blood can be taken up by sinusoidal endothelial cells, hepatocytes, and Kupffer cells in the liver (Zhang et al., 2016). Kupffer cells and ... how many gfci outlets can be on one circuitWebBivalirudin is a 20 amino-acids hirudin-analogue with a molecular mass of 2’180 Da and a half-life of ~25 minutes; it is eliminated by proteolysis and for ~20% by renal clearance . Both bind human thrombin reversibly, … how many gfci on one circuitWebAug 22, 2024 · This precaution is based on adult studies of patients with these disease states who had reduced argatroban clearance. Renal Dose Adjustments. No adjustment recommended. Liver Dose Adjustments. Moderately impaired hepatic function: Initial: 0.5 mcg/kg/min administered as a constant infusion. hout vintageWebAlthough its clearance is largely organ independent (blood proteases), the kidneys provide approximately 20% of its clearance necessitating dose adjustments with moderate renal insufficiency and its molecular properties facilitate clearance with hemodialysis. 5 Unlike the heparin–antithrombin III complex, bivalirudin exerts its effect by ... how many gfci outlets do i needWebMar 1, 2024 · The total body clearance of bivalirudin in PTCA patients with normal renal function is 3.4 mL/min/kg. Metabolism. ... Total body clearance was similar for PTCA … how many gfci in kitchenWebTraductions en contexte de "fonction rénale ou hépatique est altérée" en français-anglais avec Reverso Context : Étant donné que la clairance du sildénafil est réduite chez les personnes âgées (65 ans et plus) et chez les patients dont la fonction rénale ou hépatique est altérée, il est préférable d'amorcer le traitement à une dose de 25 mg. how many gfci outlets on a 20 amp circuit