Cryptotanshinone stat3
WebCryptotanshinone is a major tanshinone that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC 50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMPK (AMP-activated protein kinase). WebOct 27, 2024 · A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis.
Cryptotanshinone stat3
Did you know?
WebMar 2, 2024 · 基于此，本研究结果发现，脑心通胶囊中阿魏酸（2.5 μg/mL）可显著下调细胞中STAT3、Akt、ERK的mRNA表达，丹酚酸B（50 μmol/L）可显著下调细胞中JAK2和STAT3的mRNA表达，芒柄花素（25 μmol/L）和黄芪甲苷（2.5 μmol/L）分别可显著下调细胞中JAK2和Akt的mRNA表达;而部分有效 ... Webanticancer therapy, that promotes the binding of signal transducer and activator of transcription 3 (STAT3) to Cryptotanshinone has been investigated. This binding tremendously reduces both the cellular production of STAT3, and the availability of the STAT3 dimers that drive production of various cellular oxygen and electron sources [11].
WebDec 31, 2008 · Cryptotanshinone binds to STAT3 monomer and inhibits the dimerization of STAT3. To visualize cryptotanshinone inhibition of STAT3 localization in intact cells, … WebJun 6, 2013 · Cryptotanshinone inhibits STAT3 phosphorylation by binding to the SH2 domain, inhibiting nuclear translocation, and binding to its target genes for transactivation (Lu et al., 2013). Treating the ...
WebCryptotanshinone Inhibits STAT3, but Not STAT5, Signaling in K562 Cells Parallel assays were carried out in cryptotanshinone-treated K562 cells. Different from tanshinone IIA, cryptotanshinone reduced the phosphorylation level of STAT3, but not STAT5, in a dose- and time-dependent manner (Figure 3 (a) ). WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in …
WebAug 26, 2024 · Hence, this study aims to explore whether TW-37 could be a valuable therapeutic option as monotherapy in human oral cancer, as well as combination therapy with cryptotanshinone, by targeting STAT3–Mcl-1 signaling. Methods Cell culture and chemical preparation
WebMay 21, 2024 · Cell Death & Disease - Retraction Note to: A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy poole live web camerasWebCryptotanshinone inhibits STAT3 signaling to alleviate cardiac fibrosis in type 1-like diabetic rats. Phytother Res. 31(4): 638 – 646. , , [Web of Science ®], [Google Scholar] Longa EZ, … poole low tide timeshttp://shiji.cnreagent.com/s/sv273021.html sharding pythonWebMay 11, 2024 · Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation Download PDF Your article has downloaded shardingruleconfigWebJul 20, 2024 · Cryptotanshinone depletes c-Myc in CML by repressing the phosphorylation of STAT5. Decreased viability of K562 cells correlated with p-STAT5 suppression. … poole lighthouse theatre what\u0027s onWebApr 9, 2024 · Cryptotanshinone (CTN) has shown its neuroprotective and anti-inflammatory qualities in non-genetic mouse model of Alzheimer’s disease. According to bioinformatics analysis, CTN and Signal Transducer and Activator of Transcription 3 (STAT3) may interact to form a drug-target network. sharding routerWebCryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines … sharding rdbms