Hnrnp tak1 macrophage
Webgests that LPS-induced TLR4 activation abrogates TAK1 mRNA translational repression by HNRNP K and the newly synthesized kinase TAK1 boosts the macrophage inflamma … Web21 apr 2014 · Silencing of hnRNP K does not affect TAK1 mRNA synthesis or stability but enhances TAK1 mRNA translation, resulting in elevated TNF-α, IL-1β, and IL-10 mRNA …
Hnrnp tak1 macrophage
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Web2 feb 2024 · Significant liver injury and increased numbers of intrahepatic M1 macrophages were found in hepatocyte-specific TAK1-deficient (TAK1 ΔHEP) mice, peaking at 4 weeks and gradually decreasing at 8 and 12 weeks.Meanwhile, activation of STING signalling was observed in livers from TAK1 ΔHEP mice at 4 weeks and had decreased at 8 and 12 …
Web20 feb 2014 · As expected, TP decreased the phosphorylation of TAK1 at Thr 187 in the dose- and time-dependent manner, both in macrophage-like cell lines (Figure 3 B) and in murine peritoneal macrophage (Figure S3 C), which is necessary for TAK1 activation (Sakurai et al., 2000), compared to the LPS group, which suggests an inhibitory effect of … WebHeterogeneous ribonucleoprotein particle. Heterogeneous nuclear ribonucleoproteins ( hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). The presence of the proteins bound to a pre-mRNA molecule serves as a …
http://biogps.org/dataset/E-GEOD-48463/translation-control-of-tak1-mrna-by-hnrnp-k-modulates-lps-induced-macrophage-activation/ Web6 nov 2015 · ZFP36L1 mediates PMA-induced monocyte/macrophage differentiation. ( a) Western blot and real-time PCR analyses of expression of ZFP36L1 and the monocyte/macrophage differentiation markers CD11B ...
Web16 set 2024 · Macrophage Notch1 controls TAK1-mediated innate immune responses and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin. β-catenin is …
Web9 feb 2024 · TAK1 (MAP3K7) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, and is activated by a diverse set of inflammatory stimuli including … how to add mendeley to chromeWeb13 ott 2024 · M2 macrophage-derived exosomal miR-155-5p promotes the development of colon cancer by inhibiting the expression of ZC3H12B in vivo. Delivery of miR-155-5p from M2 macrophage to colon cancer cells through exosomes impaires ZC3H12B-mediated IL-6 stability reduction, which consequently induced immune escape and tumor formation (Ma … how to add mendeley to word 2007Web22 lug 2024 · HnRNP K is a heterogeneous nuclear ribonucleoprotein and has been identified as an oncogene in most solid tumors via regulating gene expression or alternative splicing of genes by binding both DNA and pre-mRNA. However, how hnRNP K affects tumorigenesis and regulates the gene expression in cervical cancer (CESC) remains to … how to add mendeley reference manager to wordWebFIGURE 6. LPS treatment of hnRNP K-depleted RAW 264.7 cells led to elevated TAK1 protein, earlier and prolonged p38 phosphorylation, and enhanced cytokine mRNA synthesis. (A) Western blot analysis (representative example of three independent experiments) of lysates generated from noninduced and LPS-stimulated RAW 264.7 … method salonWeb16 set 2024 · Macrophage Notch1 controls TAK1-mediated innate immune responses and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin. β-catenin is … how to add mendeley to word 2010Web29 mag 2014 · TAK1 was originally identified as a kinase that is involved in TGF-β signaling. 27 Interestingly, TAK1 also functions as an upstream signaling molecule of MAP kinases … methods agencyWebMajor pathways enriched for SR/hnRNP DEGs in Salmonella-infected macrophages are generally related to innate immune responses and macrophage activation, including “Role of Pattern Recognition Receptors (PRRs) in Recognition of Bacteria and Viruses,” “Communication between Innate and Adaptive Immune Cells”, and “Granulocyte … how to add memory to your pc