Laminin g domain

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August undefined, 2024

TīmeklisAbstract. A unique O-mannose-linked glycan on the transmembrane protein dystroglycan binds a number of extracellular matrix proteins containing laminin G … TīmeklisPikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is …

Basal lamina strengthens cell membrane integrity via the laminin G …

Tīmeklis2024. gada 21. marts · LAMA5 (Laminin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with LAMA5 include Bent Bone Dysplasia Syndrome 2 and Nephrotic Syndrome, Type 26.Among its related pathways are Integrin Pathway and ERK Signaling.Gene Ontology (GO) annotations related to this gene include … Tīmeklis2000. gada 15. febr. · In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal structure of the N-terminal G domain of SHBG in complex with 5alpha-dihydrotestosterone at 1.55 A resolution reveals both the architecture of the steroid-binding site and the quaternary … akani financial services

Biotinylated Anti-mouse Laminin a4 Antibody

TīmeklisInterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool. TīmeklisThe nomenclature of laminins is based on the composition of α, β, and γ chains, so that a laminin composed of α2, β1, and γ1 chains is described as laminin 211. … Tīmeklis2000. gada 1. aug. · Abstract. Laminin G domain-like (LG) modules of approximately 180–200 residues are found in a number of extracellular and receptor proteins and often are present in tandem arrays. LG modules are implicated in interactions with cellular receptors (integrins, α-dystroglycan), sulfated carbohydrates and other extracellular … aka ppo cincinnati

CDD Conserved Protein Domain Family: LamG - National Center …

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TīmeklisThe Laminin G or LNS domain (for Laminin-α, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set of extracellular proteins [1,2].It often occures in multiple copies probably serving as general protein interaction domains that bind the target proteins and other macromolecules, … Tīmeklis2024. gada 4. jūn. · Indeed, LAMA possesses five laminin-type G domain (LG) modules at the C-terminus, arranged in a tandem array, that are differentially processed under homeostatic conditions or during tissue repair ... akara capital advisors pvt ltdTīmeklis2002. gada 26. nov. · The functional importance of the α4 laminin G domain is emphasized by our in vitro and in vivo studies. In the former, we have shown that antibodies against the same G 1 /G 2 domain fragment block branching morphogenesis of endothelial cells maintained on artificial basement membrane proteins . a kappa coefficient

"Tīmeklis2024. gada 28. janv. · This gene encodes a protein that contains a N-terminal thrombospondin-type laminin G domain and several tandem arranged epilepsy … " - Laminin g domain

Laminin g domain

Entry - *120320 - COLLAGEN, TYPE XII, ALPHA-1; COL12A1

Tīmeklis2024. gada 13. apr. · Mature Laminin α4 is a subunit of Laminin 411, Laminin 421, and Laminin 423. Mature Laminin α4 is a 1792 amino acid (aa) residue protein that has a Laminin N-terminal domain, four Laminin EGF-like domains, the coiled-coil domain, and five C-terminal tandem Laminin G-like domains. The G-like domains contain …

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Tīmeklis14107 Ensembl ENSG00000083857 ENSMUSG00000070047 UniProt Q14517 n/a RefSeq (mRNA) NM_005245 NM_001081286 NM_010179 RefSeq (protein) … TīmeklisThe Laminin G or LNS domain (for Laminin-α, Neurexin and Sex hormone-binding globulin) is an around 180 amino acid long domain found in a large and diverse set …

Tīmeklis1998. gada 1. okt. · The proteins of the family typically contain two or three repeats of a laminin G domain–epidermal growth factor (EGF)–laminin G domain, also named neurexin motifs, followed by a transmembrane domain and a short cytoplasmic tail (Fig. 2A).Interestingly, the N-terminus domains within and between neurexins I, II and III … TīmeklisThe sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding protein (C4BP) and TFPI. Furthermore, the LG-domains are essential for the TFPI-cofactor function and for expression of full APC-cofactor function. The aim of the …

Tīmeklis2000. gada 3. apr. · The structure of α2LG4–5. The α2LG4–5 structure has approximate overall dimensions of 35 × 40 × 80 Å. Both LG domains, LG4 and LG5, are built up from the typical 14-stranded antiparallel β-sandwich with a disulfide bridge near the domain termini and a calcium-binding site at the opposite edge of the sandwich (Hohenester … TīmeklisThe EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described. It comprises about 30 to 40 amino-acid residues and has been found in a large number of mostly animal proteins. Most occurrences of the EGF-like domain are found in the extracellular …

Tīmeklis2024. gada 1. jūn. · A unique O-mannose-linked glycan on the transmembrane protein dystroglycan binds a number of extracellular matrix proteins containing laminin G-like (LG) domains. The dystroglycan-matrix interaction is essential for muscle function: disrupted biosynthesis of the matrix-binding modification causes several forms of …

Tīmeklis2024. gada 29. jūn. · Close-up views for the contacts between the laminin LG2 domain and the II-III loop region c or the X1 region d of the α6 β-propeller domain. ... g Laminin binding affinity of mutant α6β1 ... akappall minecraftTīmeklis2024. gada 8. marts · Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, … aka pattern recognitionTīmeklisThe C-terminal domain is composed of five laminin G (LG) domains, important for cell receptor binding to, predominantly, integrin-α7β1 and the dystroglycan protein complex (DGC; Timpl and Brown, 1996; Figure 1A). These linkages modulate communication between the basal lamina of the ECM and muscle cell cytoskeleton. They also … akarana city rifle clubTīmeklis2000. gada 1. febr. · The C-terminus of the laminin alpha chain contains a tandem of five laminin G-like (LG) domains. We report the 2.0 A crystal structure of the … akar centro educativohttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00282 a karamazov companionTīmeklisThe sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding … akarcraft discordTīmeklis2024. gada 13. nov. · Laminin G Domains of Protein S Bind and Inhibit Fixa. Blood (2024) 134 (Supplement_1): 3624. Background: Protein S (PS) is a vitamin K … akaran essential moisturizing