Phospho-p53 ser15
WebCircadian Rhythm Neuroinflammation Neuropeptides Ion Channels Neurodegenerative Disorders Amyotrophic Lateral Sclerosis Back WebThe NeuroMab™ anti-Phospho-p53 (Ser15) antibody (Rodent Specific) recognizes endogenous levels of p53 protein only when phosphorylated at Ser15. Expression Host …
Phospho-p53 ser15
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WebPhospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) (ab284565) (K966) provides a simple and complete assay in a ready to use format to visualize the nuclear translocation of activated p53 in mammalian cells. …
WebPhospho-p53 (Ser15) Antibody (MA5-15229) in ICC/IF. Immunofluorescence analysis of Phospho-p53 (Ser15) was performed using 70% confluent log phase HCT116 cells … WebOct 16, 2007 · Double-stranded DNA breaks induced by IR activate ATM by inducing autophosphorylation of the ATM kinase at Ser-1981 ( 14 ). The activated ATM kinase phosphorylates MDM2 at Ser-395 and p53 at Ser-15, the initial step of p53 activation in response to IR, which then leads to the stabilization of the p53 protein ( 15 ).
Web67826-1-Ig targets Phospho-P53 (Ser15) in WB, FC, ELISA applications and shows reactivity with Human samples. Background Information TP53, also known as P53 and NY-CO-13, belongs to the p53 family and has 9 isoforms. In SDS-Page, the observed molecular weight is about 53 kDa. WebActivation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced …
WebOct 16, 2024 · Upon genotoxic stress, ATM can directly phosphorylate p53 at Ser15 52 - 54 and, in addition, mediates p53 Ser20 phosphorylation via activation of its direct substrate CHK2, which functions as a p53 Ser20 kinase. 55 Additionally, ATM was also reported as a p53 Ser46 kinase 50 (Figure 4 b).
WebThe -p53 (Ser15) Assay is a sandwich immunoassay Phospho (Figure 1). MSD provides a plate that has been pre-coated with capture antibody for phospho-p53. flu like symptoms early pregnancy sore throatWebPhosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1. It is unclear whether AMP directly mediates phosphorylation at Ser-15. flulike symptoms the day after exerciseWebThe intense phosphorylation of p53-Ser15, combined with activation of ATM and Chk2 (involving centrioles) as well as phosphorylation of H2AX seen in the untreated mitotic … flu like symptoms pregnancy signWebApr 7, 2006 · A second site on p53, ser20, is also phosphorylated in response to DNA damage, not directly by ATM but rather mediated through Chk2. 58 As with the ser15 phosphorylation on p53, there exists ... flu like symptoms pain in neckWebThe intense phosphorylation of p53- Ser 15, combined with activation of ATM and Chk2 (involving centrioles) as well as phosphorylation of H2AX seen in the untreated mitotic … flu like symptoms from shingles vaccineWebApr 15, 2013 · However, AMPK also induces phosphorylation of p53 at Ser15, which stabilizes the protein and leads to mitochondrial accumulation of p53. At the mitochondrial surface, phospho-p53 adjoins and rearranges the Bak–Bcl-x L complex (Fig. S3N), resulting in conformational activation of Bak and apoptotic sensitization. This mechanism may act … flu like symptoms and heart attackWebThere are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in … greenfield animal control greenfield in