Sterically stabilized liposomes
網頁1997年1月24日 · These “sterically stabilized,”; or “Stealth®,”; liposomes were successfully used for the treatment of experimental cancers in vivo ( 8, 9, 10 ), and liposomes … 網頁long-circulating liposomes. We consider that such liposomes are sterically stabilized by the presence of the relevant headgroups on their surface (16). In this report we present …
Sterically stabilized liposomes
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網頁1992年4月1日 · Sterically stabilized liposomes. Reduction in electrophoretic mobility but not electrostatic surface potential Author links open overlay … 網頁2013年12月31日 · Recently, sterically stabilized nanoliposomes have been reported to be used in the formulation of complexes of different metal ions (Na, K, Mn, Co, Ni) with salinomycin (an antibiotic and...
網頁Sterically stabilized liposome-containing PTX (PTX-SSL) was prepared by a similar procedure, except that the DSPE-PEG-H 7 K(R 2) 2 replaced by DSPE-PEG and 5% glucose solution was used as the hydration medium. The preparation of … 網頁DAPI，即2- (4-Amidinophenyl)-6-indolecarbamidine dihydrochloride，也称DAPI dihydrochloride，分子式为C 16 H 15 N 5 ·2HCl ，分子量为350.25 ，CAS Number 28718-90-3。 DAPI是一种可以穿透细胞膜的蓝色荧光染料。 和双链DNA结合后可以产生比DAPI自身强20多倍的荧光。 和EB (ethidium bromide)相比，对双链DNA的染色灵敏度要高很多 …
網頁1998年9月1日 · The large unilamellar liposomes were composed of 1, 2-dioleolyl-sn-glycero-3-phosphatidylcholine with and without the addition of either a positively charged lipid, 1, 2-dioleoyl-3-dimethylammonium propanediol (DODAP), or a negatively charged lipid, 1,2-dioleolyl-sn-glycero-3-phosphatidylserine. 網頁2014年4月15日 · Particularly, PEGylated liposomes, also known as sterically stabilized liposomes (SSL) (Lasic, 1996; Silvander, 2002 ), have significantly prolonged circulation time of drugs in vivo due to less phagocytosis by reticuloendothelial system (RES), and therefore improved the efficacy of cancer therapy.
網頁1992年8月14日 · Several studies have shown that liposome stability in pla,~ma depends on the relative concentrations, lipo- some size and lamellarity, lipid composition, and the incubation temperature [5fl,53,54]. The kinetics of lipo- some leakage depend on the type of label used with (in) the liposome but normally show single exponential release profiles.
網頁The efficacy of 20(S)-camptothecin (CPT), free and incorporated into sterically stabilized liposomes, has been investigated in vitro against Leishmania donovani promastigotes and in vivo in a murine model of visceral leishmaniasis. Incubation of L. donovani promastigotes with free or liposomal CPT i … nics call number網頁2015年5月29日 · Liposomes are artificially prepared lipid vesicles containing an internal aqueous phase. Their characteristics, which include flexibility of composition, biocompatibility, biodegradability and non-immunogenicity, make them suitable for … nics burgers chatsworth網頁2013年2月22日 · The following methods are used for the preparation of liposome: 1. Passive loading techniques 2. Active loading technique. Passive loading techniques include three different methods: 1. Mechanical dispersion method. 2. Solvent dispersion method. 3. Detergent removal method (removal of non-encapsulated material) [ 18, 19 ]. now serving raleigh網頁Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study. Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. nowserving ph網頁1991年11月18日 · We propose that stabilization results from local surface concentration of highly hydrated groups that sterically inhibit both electrostatic and hydrophobic … nics category letter網頁1991年12月15日 · Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. The results obtained in this study establish that … nics burgers okla city ok網頁2024年3月8日 · Numerous polymers have been used to increase the stability of the liposome in blood vessels by forming a polymeric barrier on the surface of liposome. This polymer-mediated protection is also described as “steric stabilization” (Torchilin 2012 ). nics calculation method