Thioholgamide a
WebThioholgamides are ribosomally synthesized and posttranslationally modified peptides (RiPPs), with potent activity against cancerous cell lines and an unprecedented structure. Despite being one of the most structurally and chemically complex RiPPs, very few biosynthetic steps have been elucidated. H … WebMay 19, 2024 · Thioholgamide A (thioA) is a ribosomally synthesized and post-translationally modified peptide, which has been identified as a …
Thioholgamide a
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WebLateef Kayode Jakande was born in the Epetedo area of Lagos Island, Lagos State on July 29, 1929. Both parents are from Omu-Aran, Kwara State . He studied at the Lagos public … WebOct 17, 2024 · Thioholgamides display improved cytotoxicity in the submicromolar range against a range of cell lines and an IC 50 of 30 nM for thioholgamide A against HCT-116 …
WebBGC0001802. Short description. thioholgamide A biosynthetic gene cluster from Streptomyces malaysiense. Status. Minimal annotation: yes. A minimal annotation only contains information on the BGC loci and one or more linked chemical product (s) Completeness: Unknown. Whether the loci encodes everything needed for the pathway … WebTVA-YJ-2 [synonyms: thioholgamide A] Copy SMILES. Chemical database entries NPAtlas. List of genes involved in compound(s) production. Identifiers Position Product Functions Evidence Extra; IF43_RS42015; WP_199922668.1; 260440 - 260601 (-) hypothetical protein: copy AA seq copy Nt seq. IF43_RS0103380; WP_030193536.1;
WebJul 1, 2024 · Thioholgamide B exhibited lower activity compared to thioholgamide A [10a]. Thioalbamides showed strong antiproliferative activity on tumor lines including luminal … WebMay 19, 2024 · Natural products represent powerful tools searching for novel anticancer drugs. Thioholgamide A (thioA) is a ribosomally synthesized and post-translationally modified peptide, which has been …
WebMay 22, 2024 · However, fermentation of the fourth strain, Streptomyces malaysiense MUSC 13657, resulted in the production, isolation, and structural characterization of two novel compounds, thioholgamide A and B. Thioholgamide A (31) showed anticancer activity more pronounced than that of thioviridamide A. Both groups were thus independently able to …
WebReference lanthipeptide-class-v thioamitides Similarity score Type Compound(s) Organism; BGC0001802.1: 2.00: RiPP: thioholgamide A, thioholgamide B: Streptomyces malaysiense blackburn toyotablackburn tow trucksWebJul 5, 2024 · The fermentation extracts were subsequently screened by liquid chromatography-mass spectrometry (LC-MS) for TLM production based on their predicted mass. Four thioviridamide-like molecules (TLMs) were successfully identified using this methodology, including thioholgamide A, thioholgamide B [10a], thioalbamide and … blackburn track pump sparesWebOct 5, 2024 · Thioholgamide A (thioA) is a ribosomally synthesized and post-translationally modified peptide, which has been identified as a product of Streptomyces sp. MUSC 136T. gallbladder medication over the counterWebOct 17, 2024 · Thioholgamides display improved cytotoxicity in the submicromolar range against a range of cell lines and an IC 50 of 30 nM for thioholgamide A against HCT-116 cells. Herein, we report the isolation and structural elucidation of thioholgamides A and B, a proposed biosynthetic cluster for their production, and their bioactivities against a ... blackburn tps-2 bike pump partsWebThioholgamide A (thioA) is a ribosomally synthesized and... DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing … blackburn track pumpWebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. blackburn town hall phone number